The Curious Progression of Hepatitis C

Hepatitis C, a serious infection that is passed between people only by blood-to-blood contact was only given its official name in 1989. Before that, as scientists were trying to determine if it was different from the other types of Hepatitis and if so how, it was simply referred to as non-A or non-B Hepatitis. What an odd name for a disease that currently infects at least four million people in the Untied States and over one hundred and seventy million people globally.

Hepatitis C is an odd one because so much of the time it is not obvious when someone has the infection. Seventy percent of those infected show no symptoms, this makes it very hard to diagnose. It is believed that during the acute stage, the first six months, twenty five percent of people who are infected become uninfected for reasons that no one is able to determine.  This is known as spontaneous viral clearance.

For the other seventy five percent of those infected with the Hepatitis C virus, also now as HCV, it becomes chronic.   The only problem with these figures is that they are a bit of a guess.  The number of people that are lucky enough to have a spontaneous viral clearance could be much higher based on the fact that so many people don't realize that they are infected until the HCV has been around for a long time and symptoms start to show. There are no tests that will be able to tell researchers what the exact figures are at this time.

At one time it was common practice to not treat those who were considered to still be in the acute stage. This was because they hoped that by doing nothing it would just go away.  Recent studies are showing that was wrong and that if Hepatitis C is treated early there is a ninety percent success rate. Not only that but the treatment time is cut in half.

Once passed the infection period of six months the Hepatitis C virus now becomes considered a chronic infection.  Interestingly of those who remain untreated it will take thirty percent of them about twenty years to develop cirrhosis of the liver. The next one third will take another ten years on top of that and the last third will take so long that they will die before the liver develops the cirrhosis. There are upwards of one hundred and fifty thousand new cases of HCV each year in the Untied States. People with HIV are very likely to also be infected with HCV as both diseases have similar transmission requirements. Around seventy percent of all intravenous drug users have Hepatitis C.

Research continues on what can be done to control this very serious infection. Unlike Hepatitis A or B there is currently no vaccine.  But recent studies have made some progress and a new vaccine is in the testing stages with human subjects. So far it is having significantly successful results. The studies are continuing. 

Hepatitis news on the Web

ZymoGenetics Acquisition Highlights Competitive Hepatitis C Treatment Race - OneMedPlace (blog)

The Star-Ledger - NJ.com

ZymoGenetics Acquisition Highlights Competitive Hepatitis C Treatment Race
OneMedPlace (blog)
Approximately 3.2 million people in the US are chronically infected with hepatitis C, according to the US Centers for Disease Control, and ZymoGenetics' ...
Bristol-Myers Squibb Hopes to Strengthen Hepatitis C Pipeline With Latest BuySeeking Alpha (blog)
Stock Picks: Best Buy, Bristol-Myers Squibb, MGM ResortsBusinessWeek
Zacks Analyst Blog Highlights: Bristol-Myers Squibb, ZymoGenetics, Family ...Trading Markets (press release)
Forbes -New York Times (blog) -Bloomberg
all 428 news articles »

For biotechs, no easy task - Boston Globe

For biotechs, no easy task
Boston Globe
Hepatitis C, a serious medical problem around the world, is also one of the most important disease targets for the state's biotechnology ...
Vertex reports positive results from Phase III hepatitis trialTrading Markets (press release)
Telaprevir Achieves 65% SVR in REALIZE StudyDrug Discovery & Development

all 3 news articles »

Vertex hepatitis C drug helps the hard-to-treat - BusinessWeek

TopNews United Kingdom (blog)

Vertex hepatitis C drug helps the hard-to-treat
BusinessWeek
Vertex Pharmaceuticals Inc. said Tuesday that a late-stage clinical trial showed its hepatitis C drug candidate telaprevir proved effective for patients who ...
Vertex Maintains Lead Over Merck In Hepatitis CForbes (blog)
65% of People Whose Prior Treatment for Hepatitis C Was Unsuccessful Achieved ...MarketWatch (press release)
Vertex Cures Hard-to-Treat Hep C PatientsTheStreet.com
Bloomberg -Xconomy -TopNews United Kingdom (blog)
all 50 news articles »

Idenix hep C drugs on clinical hold; shares plummet - Reuters

RTT News

Idenix hep C drugs on clinical hold; shares plummet
Reuters
O) said US health regulators halted all trials of two of its experimental hepatitis C drugs on safety concerns, putting the breaks on a potential ...
Idenix: Two Hep C Drugs on Clinical HoldTheStreet.com
Idenix Shares Plunge As FDA Puts Hepatitis C Drugs On Clinical Hold - UpdateRTT News
FDA halts Idenix Hep C drug targets on safety concernsMass High Tech
FierceBiotech -Capital.gr (press release) -Bloomberg
all 71 news articles »

Bay State companies put 'superbugs' in bull's-eye - Boston Herald

Bay State companies put 'superbugs' in bull's-eye
Boston Herald
Massachusetts firms are also developing 18 percent of all hepatitis C medicines and vaccines, data released by the trade group Pharmaceutical Research and ...
Two Hepatitis C Drug Candidates on Hold Because of Adverse EventsMedscape
Idenix Provides Update on HCV Clinical Development ActivitiesPR-CANADA.net (press release)
FDA halts Idenix drug studies due to side effectsBusinessWeek
pharmabiz.com
all 5 news articles »

Facts about hepatitis C - Helium

Facts about hepatitis C
Helium
Hepatitis C is a disease caused by a virus that lives in your liver cells. This virus can cause liver inflammation, and over time become ...
Research and Markets: This Special Expert Review of Anti-Infective Therapy ...Business Wire (press release)

all 4 news articles »

Patents drive up treatment costs of Hepatitis C - Daily News & Analysis

Patents drive up treatment costs of Hepatitis C
Daily News & Analysis
“Hepatitis C is a completely neglected disease. There is no government support, no vaccine, and existing medicines are incredibly expensive,” says Pardesi. ...

and more »

A Personal Plea for Better HIV & Hepatitis Prevention Policy - Huffington Post (blog)

A Personal Plea for Better HIV & Hepatitis Prevention Policy
Huffington Post (blog)
"I want to test you for hepatitis C and HIV," my doctor said to me during a routine physical in 2000. I'd been in recovery for 15 years, after battling drug ...

Hepatitis C sufferers tell how 'manky' blood devastated their lives - Scotsman

Herald Scotland

Hepatitis C sufferers tell how 'manky' blood devastated their lives
Scotsman
SCOTTISH patients infected with hepatitis C or HIV through blood products have revealed the devastating impact on their lives as the first ...
Call to extend inquiry into blood scandalHerald Scotland
Infected Scottish Patients Call in For another Round of Inquiry into Blood ScandalTopNews United States
Contaminated blood probe report outThe Press Association
BBC News
all 59 news articles »

Hepatitis C Spikes Among Young Heroin Users - WBUR

Hepatitis C Spikes Among Young Heroin Users
WBUR
The Department of Public Health says infection rates for Hepatitis C in 15- to 25-year-olds have almost doubled since 2002. But there's no money in this ...


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